By Dr. Carlon Colker, M.D.
The presence of myostatin (a genetic protein found in all humans) has been identified as the force responsible for limiting the body’s ability to build extreme amounts of muscle. In other words, it is the primary cause responsible for limiting muscle growth despite all your efforts and years of heavy training in the gym.
In a 2001 published study from Johns Hopkins University, a reduction in serum myostatin as little as a 20% was shown to result in a significant increase in muscle mass and an increase in muscular strength. But for those that want to gain muscle, this has always been a struggle. In order to overcome our myostatin levels, we have to train with weights and follow a special diet. Some resort to using anabolic steroids or growth hormone, all in an effort to surpass their natural potential.
But now with MHP’s MYO-X, there is a new breakthrough that goes beyond hormonal stimulus and can significantly reduce myostatin levels.
Carlon Colker, M.D., FACN
Sports Performance Physician
Robert Hariri, M.D., Ph. D.
Vincent Giampapa, M.D.
Age Management Specialist
Scientists Call Myostatin Inhibition A Monumental Sports Nutrition Advancement
Myostatin is a powerful negative regulator of skeletal muscle mass that restricts muscle growth. Scientists have been eagerly searching for a way to reduce myostatin and increase muscle building for the treatment of muscle loss. Every bodybuilder on the planet would want to have lower levels of myostatin. And now they can with the world’s first natural myostatin inhibitor, clinically tested MYO-X. While MYO-X will certainly not eliminate myostatin, it is clinically proven to significantly reduce myostatin levels. It also supplies critical proteins, peptides and bio-active growth factors to increase muscle building potential.
Since the discovery of myostatin in 1997, scientists have been intrigued by its actions and have sought methods of intervention to reduce myostatin levels and induce muscular growth. For instance, research at Johns Hopkins University as early as 2001 showed that a 20% reduction in exercise-induced serum myostatin resulted in significant gains in muscle mass. As a result, sports physicians began studying this compound in hopes of introducing some type of viable myostatin inhibitor to athletes. At the forefront of this research was Carlon Colker, M.D., a dedicated medical doctor with a vision of building bigger, stronger athletes.
REAL EXAMPLES OF MYOSTATIN DEFICIENT EFFECTS
Documented cases of myostatin deficiency in mammals, including humans, display astonishing muscular growth and reduced body fat levels. Researchers have been studying the rare accelerated growth of a German child deficient in myostatin since he was first referenced in the New England Journal of Medicine in 2004, while the tremendous muscularity of the Belgian Blue bull and “Bully” Whippet dog breed are other prime examples of the absence of myostatin in animals.
( Click Images Below to Enlarge )
Revolutionary Breakthrough In Myostatin Inhibitor Technology Shows Huge Potential For Bodybuilders!
For decades, the medical community (and bodybuilders) have been urgently searching for a mechanism that would inhibit the production of myostatin, a genetic protein responsible for limiting muscle growth in humans. Spurred by scientists’ widely held belief that myostatin inhibition represents a powerful strategy for promoting significant muscular gains, the principle researchers involved in this area of inquiry have been relentless in their efforts to isolate a viable myostatin inhibitor and make it available to athletes. Now it appears that their efforts have been rewarded with the development of the highly bio-active supplement MYO-X.
Carlon Colker, M.D., along with other doctors and scientists from around the world, identified and isolated a natural bio-active compound that goes through a proprietary High Grade Handling process and carefully preserves and magnifies the concentration of 80 proteins, 700 peptides and numerous biologically active growth factors absolutely unique to the patent pending compound, MyoT12®, the active ingredient in MYO-X, functions as a modulator and antagonist to myostatin production and is validated and backed by extensive laboratory testing, human clinical studies, and peer reviewed and published results. One key study demonstrated that MyoT12 reduced serum myostatin levels up to 46% with a single serving. This is a very significant breakthrough for bodybuilders, athletes and even aging adults. Myostatin is present in all of us and regardless of how hard you train, myostatin will limit your muscle building potential. Myostatin reductions such as these may help counter the forces that have restricted your ability to build more muscle. In addtion, the critical proteins, peptides and bio-active growth factors in MYO-X could open the door to new muscle building potential. Under exclusive license, MHP’s MYO-X has emerged as a powerful approach to myostatin inhibition for all athletes!
Clinical Study Reveals Unprecedented 46% Reductions In Myostatin In Just 12 Hours!
MYO-X’s key active ingredient, MyoT12®, has been shown in a clinical study to reduce serum myostatin in study subjects by an average of 46% in 12-18 hours with just a single serving! 100% of all human clinical test subjects showed significant reductions in myostatin. The average serum myostatin declined to 12.6 pg/mL with every subject responding positively. This was a staggering average 46% drop in myostatin from baseline across all subjects. Finally, at the 24-30 hour time point with a mean value of 28.1 pg/mL, the average myostatin level completely normalized.†
( Click Chart on Right to Enlarge )
Scientific Community’s In-Depth Look At Myostatin
Since the discovery of myostatin in 1997, scientists have been intrigued by its actions and have sought methods of intervention to reduce myostatin levels and induce muscular growth. For instance, research at Johns Hopkins University as early as 2001 showed that a 20% reduction in exercise-induced serum myostatin resulted in significant gains in muscle mass. As a result, sports physicians began studying this compound in hopes of introducing some type of viable myostatin inhibitor to athletes. Below is a list of some of the most important research studies regarding myostatin’s role in muscle building and its use as an ergogenic aid for sports performance.
- Myostatin and the control of skeletal muscle mass.Se-Jin Lee and Alexandra C. McPherron (1999), Current Opinions in Genetics and Development, 9:604-607.
- Regulation of myostatin activity and muscle growth. Se-Jin Lee and Alexandra C. McPherron (2001), Proceedings of the Natural Academy of Sciences, USA 98:9306-9311.
- Suppression of body fat accumulation in myostatin-deficient mice, Alexandra C. McPherron and Se-Jin Lee (2002), Journal of Clinical Investigation 109:595-601.
- Regulation of muscle mass by myostatin.Se-Jin Lee (2004), Annual Review of Cell and Development Biology, 20:61-86.
- Gross muscle hypertrophy in a child associated with a myostatin (GDF-8) mutation. Markus Schuelke, Kathryn R. Wagner, Leslie Stolz, Christoph Hubner, Thomas Riebel, Wolfgang Komen, Thomas Braun, James F. Tobin, and Se-Jin Lee (2004), New England Journal of Medicine, 350 :2682-2688.
- Randomized blind comparison of follistatin in standard store-bought unfertilized chicken eggs versus standard store-bought fertile eggs, Colker, C., Journal of the American College of Nutrition, Volume 25, No. 5; Abstract 65; October 2006.
- Absorption profile and hormonal influences of fertile egg yolk ingestion in the human, Colker, C., Journal of the American College of Nutrition, Volume 25, No. 5; Abstract 66; October 2006.
- Sprinting without myostatin: a genetic determinant of athletic prowess. Se-Jin Lee (2007) Trends in Genetics,23:475-477.
- Follistatin resides primarily in the yolk membrane, Colker, C., Reviewed and accepted for poster presentation at the 2008 Conference on Post-Translational Modification: Detection and Physiological Evaluation for the American Society for Biochemistry and Molecular Biology; Category: Unusual Modifications; Poster 5, Abstract 8; October 2008.
- Effect of debulked fertile egg yolk ingestion on serum myostatin levels, Colker, C. Reviewed and accepted for poster presentation at the 2008 Conference on Post-Translational Modification: Detection and Physiological Evaluation for the American Society for Biochemistry and Molecular Biology; Category: Unusual Modifications; Abstract 10; October 2008.
- Effect of high-grade handling of fertile egg yolks on follistatin concentration,, Colker, C., Journal of the American College of Nutrition, Volume 28, No.3, Abstract 47; June 2009.
- Effect on serum myostatin levels of high-grade handled fertile egg yolk powder, Colker, C., Journal of the American College of Nutrition, Volume 28, No.3, Abstract 47; Page 309. October 2009.
- Regulation of muscle mass by follistatin and activins. Se-Jin Lee, Yun-Sil Lee, Teresa A. Zimmers, Arshia Soleimani, Martin M. Matzuk, Kunihiro Tsuchida, Ronald D. Cohn, and Elisabeth R. Barton (2010), Molecular Endocrinology, 24:1998-2008.
- Metabolic functions of myostatin and Gdf11, Alexandra C. McPherron,Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry, December 2010; 10(4): 217–231.
- Novel intriguing strategies attenuating to sarcopenia, Kunihiro Sakuma1 and Akihiko Yamaguchi, 1.) Research Center for Physical Fitness, Sports and Health, Toyohashi University of Technology, 1-1 Hibarigaoka, Tenpaku-cho, Toyohashi 441-8580, Japan; 2.) School of Dentistry, Health Sciences University of Hokkaido, Kanazawa, Ishikari-Tobetsu, Hokkaido 061-0293, Japan.
- The central role of myostatin in skeletal muscle and whole body homeostasis. B. Elliott, D. Renshaw, S. Getting and R. Mackenzie, Infection & Immunity Group, Department of Human & Health Science, School of Life Sciences, University of Westminster, London, UK.
A significant breakthrough for bodybuilders looking to increase muscular performance.” – Muscular Development
A monumental advancement in performance nutrition. MHP is once again leading the industry into a new frontier.” – PLANET MUSCLE & BODYBUILDING Magazine
“I’ve never experienced anything like MYO-X. This stuff has extremely powerful effects.” – Victor Martinez, IFBB Pro Bodybuilder
If you’re looking to get bigger and stronger, you need MYO-X. The bio-active growth factors help activate muscle growth and speeds recovery faster than anything I’ve ever taken.” – Brian Shaw, World’s Strongest Man