The One-A-Day Hardcore Fat Burner!

DREN belongs to a powerful new class of compounds called mesolimbic beta agonists, which have extremely powerful fat burning and euphoric activities. Drenbuterol is a patent pending compound scientifically formulated to stimulate both metabolic and mesolimbic pathways for extreme thermogenic fat burning and neurotropic “feel good” sensory. Each DREN capsule provides the maximum 409mg dose of Drenbuterol and should only be administered once daily and not be used with other stimulants. When taken as directed, DREN will help stimulate the thermogenic fat burning process, increase energy levels, help control appetite and elicit a state of heightened mental euphoria and well being.

Fat Loss Breakthrough:

DREN WILL TRANSFORM YOUR BODY AND ALTER YOUR MIND

• Mesolimbic Beta Agonist Fat Burning Agent
• The Most Powerful Thermogenic Fat Burner
• Extreme “Feel Good” Sensation
• Helps Curb Appetite
• Exclusive Beta-Methoxy Phenylethylamine

Scientists have been looking at the basic form Beta-Phenylethyamine (also called Beta-PEA) for years, but unfortunately its short half-life prevented this compound from ever being very effective. However, this new form isn’t just showing promise, its showing amazing results. And while Beta-Methoxy-Phenylethylamine is the new General in the war against fat a few good soldiers have been added to DREN for total annihilation of stubborn adipose FAT!

Advanced Pharmacological Approach To Fat Annihilation!

DREN uses an advanced pharmacological approach to trigger the process of lipolysis for maximum fat burning. DREN (with a patent pending compound) belongs to a powerful new class of compounds called mesolimbic Beta Agonist Fat Burning Agents. DREN possesses very selective and powerful beta-adrenergic fat burning activity. Plus in addition to extreme thermogenic effects, DREN also has powerful psycho-active euphoric effects.

Step 1: Sympathomimetic Thermogenic Activation!

Beta-Methoxy Phenylethlyamine (also called Beta-Methoxy PEA) is an exciting ingredient used in DREN. Beta-Methoxy-PEA works in part by increasing noradrenaline (NA) release from sympathetic nerve terminals. As a sympathomimetic, Beta-Methoxy PEA acts to stimulate the sympathetic nervous system. It does this by causing pre-synaptic nerve terminals to release norepinephrine, or what is commonly called noradrenaline (NA), into the synaptic space. It also has the effect of increasing circulating adrenaline, the body’s chief beta-2 agonist. Noradrenaline, once released into the synaptic space, interacts with adrenergic receptors on the surface of adipocytes (fat). This initiates a sequence of events within the adipocyte that increases lipolysis (the breaking down of fatty acids) by the enzyme hormone sensitive lipase (HSL). This fat burning effect is dependent on long and steady activation of the receptor by the agonist and is what makes Beta-Methoxy PEA so critical and why it is considered more effective than other Beta-PEA formulas.

Beta-Methoxy PEA is effective by virtue of its long half-life (stays in the body longer) as well as its affinity to be absorbed in fat tissue and better permeate the blood/brain barrier. In contrast, the half-life of many other Beta-PEA forms is only minutes as enzymes quickly metabolize them and are less lipophilic, which prevents significant concentrations from reaching the brain – therefore psychoactive and weight loss effect are more difficult to be achieved. Beta-Methoxy PEA does not have to worry about being broken down by these enzymes due to its unique configuration. The beta “Methoxy” moiety on this compound protects it and allows for increased absorption across the blood brain barrier and deep penetration into the fatty tissues of the brain where it interacts with the adrenergic receptors. This increase in noradrenaline and adrenergic receptors activation increases cAMP levels in fat cells (increasing its breakdown) and muscle cells (increasing protein synthesis). Beta-Methoxy-PEA’s unique configuration or moiety is what gives it its long duration of action, its exceptional ability to permeate fat tissue and powerful fat burning effects. I can’t emphasize the point enough: it’s the “Methoxy” in Beta-Methoxy-PEA that makes it unmatched by other forms of Beta PEA.

In addition, Beta-Methoxy Phenethylamine’s enhanced moiety and ability to better penetrate the blood brain barrier elicits a euphoric “feel good’ neuro-sensory experience. Beta-Methoxy-PEA, is believed to function as a neuromodulator or neurotransmitter and elicits psychoactive effects on the body while burning body fat. Beta-Methoxy Phenethylamine freely enters the brain barrier and triggers a cascading release of norepinephrine, dopamine and serotonin and stimulates the mesolimbic reward pathway, causing euphoria and sensory excitement.

Step 2: The Inclusion of an Alpha 2 Agonist works to further Enhance Beta-Methoxy PEA fat burning!

While Beta-Methoxy-PEA by itself is a remarkably effective thermogenic, the scientists at MHP wanted to take fat burning to a new level. Once we isolated Beta-Methoxy-PEA and saw its similar yet superior mechanisms of action we knew we could do it.

In response to Beta-Methoxy-PEA’s beta-adrenergic stimulation, negative feedback mechanisms are activated as well. This negative feedback can shutdown lipolysis (fat burning). The stimulation of the Alpha 2 receptor as well as the production of phosphodiesterases and adenosine occurs. The alpha 2 receptor, phosphodiesterases and adenosine try to slow down or halt the fat burning process. Therefore, measures had to be taken to maximize Beta-Methoxy-PEA’s actions in the body and minimize negative feedback mechanisms.

All forms of Beta-PEA are considered non-selective adrenergics through the release of noradrenaline because they don’t just active one type of receptor. Unfortunately, noradrenaline functions as its own negative feedback signal by activating both the beta and alpha adrenergic receptors. As you recall, the stimulation of beta receptors is good as it initiates the fat burning process, but the Alpha 2 receptors can actually shut down lipolysis (fat burning). MHP scientists added Yohimbine Bark Extract to the DREN formula to help by pass Alpha 2 receptor binding and increases the effectiveness of DREN. Natural Alkaloids in Yohimbe Bark are selective alpha 2 antagonists and can thus short circuit this feedback loop, maximizing noradrenaline levels and the overall fat loss actions of Beta-Methoxy PEA. What we have created is a mechanism of action, which is long acting activation on the beta receptor with little to no activity at the alpha receptor, resulting in one of the most powerful thermogenic activity in adipose tissue possible.

Step 3: Phosphodiesterase Inhibition and Adenosine Receptor Interference

Most people like caffeine because of its stimulatory and energizing effects. But caffeine has a much more important role in DREN. Stimulation of Beta-adrenergic receptor also means an increase in phosphodiesterase and adenosine activity. Phosphodiesterase (PDE) acts to hydrolyze cAMP into inactive fragments while adenosine inhibits cAMP accumulation halting the stimulation of HSL and the fat burning process. Caffeine possesses the ability to inhibit phosphodiesterases within the cell and has even been shown to have the ability to prevent some re-uptake of norepinephrine while also acting as an adenosine receptor blocker. Caffeine provides important powerful synergies to maximize DREN’s fat burning effects.

Step 4: Powerful Psycho-active “Feel Good” Neurostimulation

The mind is a powerful thing! DREN will not only transforms your body with the most powerful fat burning thermogenic experience, it will also enhance your mind and put you is a place you want to be – “On Top of The World”. There is no denying Beta-Methoxy-PEA is very psycho-active and helps trigger a euphoric “feel good response”. To further enhance DREN neuromodulator activity L-5-Hydroxytryptophan has also been added to the formula. L-5-Hydroxytryptophan is a naturally occurring amino acid, a precursor to the neurotransmitter serotonin with feel good and appetite sequestering properties. L-5-Hydroxtryptophan like Beta-Methoxy-PEA also passes through the blood brain barrier into the brain. It’s psychoactive action are thought to be derived from its effect on serotonin synthesis in central nervous system tissue. It is believed that a high supply of L-5-Hydroxytryptophan causes the brain’s serotonin-producing neurons to increase production leading to increased serotonin release. The serotoninergic system is known to modulate mood, emotion, sleep and appetite and thus is implicated in the control of numerous behavioral and physiological functions. L-5 Hydroxytryptophan helps to keep serotonin and norepinephrine levels in balance therefore increasing metabolism and fat loss through synergistic actions with other ingredients in DREN. The end result is an extreme “feel good” state.

How does it work?

Dren uses an advanced pharmacological approach to trigger the process of lipolysis for maximum fat burning called Beta-Methoxy Phenylethlyamine (Beta-Metoxy PEA). Dren belongs to a powerful new class of compounds called mesolimbic Beta Agonist Fat Burning Agents. Dren poses more selective and powerful beta-adrenergic fat burning activity than similar products. Dren also has powerful psycho-active euphoric effects.

Who should take it?

Dren should be consumed by anyone looking for extreme fat burning, steady “no crash” energy and extreme mental focus.

How should I take it?

1 capsule of Dren should be taken 30-45 minutes before workout. On non-workout days, take 1 capsule before breakfast.

Did you know?

Dren is the fat burner to contain the very powerful ingredient Beta-Methoxy Phenylethlyamine (Beta-Metoxy PEA).